Plant Cell and Developmental Biology

ZHU Lab .

Welcome to the Zhu Lab! We’re fascinated by how living organisms adjust their growth to the changing environments. We use crop roots to explore these amazing adaptations. Our work connects multiple scales, from molecules and cells to whole organs, to understand how roots grow and respond to environmental challenges. We grow roots and grow together!

1.
Year
Of The Lab’s
Journey

Great Experience

A deep and ongoing commitment to advancing the field of plant development

Many of life’s failures are people who did not realize how close they were to success when they gave up
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Molecule.

I am fascinated by the molecular mechanisms that drive plant development. The interplay of small molecules—such as DNA, RNA, proteins, and metabolites—can lead to the emergence of complex plant morphology.

Currently, I mainly use single-cell and spatial transcriptomics to unravel the molecular processes governing rice root development and its responses to soil stresses.

See Project

Cell.

My research explores the cellular principles underlying organ development, focusing on the dynamic behavior of rice roots.

By integrating 4D cellular growth tracking with cell-based computational modeling, I aim to uncover how interactions between cellular processes and environmental cues drive organ growth.

See Project

Organ.

Circumnutation plays a vital role in root penetration and navigation through obstacles (Taylor et al., 2021 PNAS). My research aims to uncover its broader biological significance at the organ level, particularly in how crop roots adapt their circumnutation frequency and amplitude to cope with various abiotic and biotic stresses.

See Project

Lab Members

2025 - present
Mingyuan Zhu PI

Ph.D. Plant Biology
Cornell University

2025 - present
Li Feng Postdoc Associate
Connect:

Email: li.feng@ag.tamu.edu
GitHub: https://github.com/fionaliii/
X: https://x.com/LiFeng0630
LinkedIn: https://www.linkedin.com/in/fionaliii/
Google Scholar: https://scholar.google.com/ citations?user=xu9oAuAAAAAJ&hl=en


Research Interests:
My research combines bioinformatics and experimental approaches to explore the molecular mechanisms and evolutionary history of root circumnutation, a key but understudied trait in plant development. Using single-cell and spatial transcriptomics, I map cell-type-specific and spatially resolved regulatory networks that control circumnutation and stress responses. Through this work, I aim to uncover how complex traits arise, evolve, and enable plants to adapt to diverse environments.

2025 - present
Medhavinee Mijar Research assistant

Medha has MSc. in Microbiology from University of Pune, India. Her research interests focus on understanding plant responses to environmental stresses, with a particular emphasis on the submergence response of Oryza sativa (rice). She is passionate about exploring the molecular and physiological mechanisms that enable plants to adapt to challenging conditions.
Outside the lab, she enjoys spending time with her family, cooking traditional Indian dishes, knitting and watching TV shows.

Contact : medhavinee.mijar@agnet.tamu.edu
linkedin: linkedin.com/in/medhavinee-mijar-900692307

 

Lab News

August 1st, 2025
Zhu Lab officially opened

BCBP Building,
Texas A&M University
College Station, TX USA
https://bcbp.tamu.edu/people/zhu-mingyuan/

2020 August - present
Postdoc associate
“Mingyuan Zhu”

Dr. Philip BENFEY’s laboratory, Duke University, HHMI, Durham, NC USA

https://sites.duke.edu/benfey/

2014 April – 2020 May
Research Assistant (PhD Candidate)
“Mingyuan Zhu”

Dr. Adrienne ROEDER’s laboratory, Cornell University, Ithaca, NY USA

https://roeder.wicmb.cornell.edu/the-roeder-lab/

February 2018 - April 2018
Research Assistant (Short-term visiting collaborator)
“Mingyuan Zhu”

Dr. Arezki BOUDAOUD’s laboratory, ÉNS de Lyon, Lyon, Auvergne-Rhône-Alpes France

June 2012 - August 2012
Research Assistant (Summer Intern)
“Mingyuan Zhu”

Dr. Laura OLSEN’s Laboratory, The University of Michigan, Ann Arbor, MI USA

November 2009 - May 2013
Research Assistant (Undergraduate)
“Mingyuan Zhu”

Dr. Dong LIU’s Laboratory, Tsinghua University, Beijing, China

Conference talks

New York USA, August 2024
2024 Weill Institute Summer Retreat (Invited speaker)
“By Mingyuan Zhu”

“Single cell and spatial transcriptomics reveal how rice root tissues adapt to soil compaction”

Michigan USA, August 2024
3rd Plant Cell Atlas (PCA) Symposium (Invited speaker)
“By Mingyuan Zhu”

“Single cell and spatial transcriptomics reveal how rice root tissues adapt to soil compaction”

California USA, July 2024
The 34th International Conference on Arabidopsis Research (ICAR 2024)
“By Mingyuan Zhu”

“Single cell and spatial transcriptomics reveal how rice root tissues adapt to soil stress”

California USA, January 2024
Plant & Animal Genome Conference 2024 (Invited speaker)
“By Mingyuan Zhu”

“Exploring genetic adaptation and single-cell-level responses to soil compaction in wheat and rice”

New York USA, November 2023
Cold Spring Harbor Laboratory Meeting - Plant Genomes, Systems Biology & Engineering
“By Mingyuan Zhu”

“Integrating single-cell and spatial transcriptomics to study rice root responses to soil compaction”

North Carolina USA, November 2022
Duke DCMB seminar series
“By Mingyuan Zhu”

“Integrating single-cell and spatial transcriptomics to understand rice root development”

Vermont USA, July 2022
Mechanisms of Plant Development, FASEB
“By Mingyuan Zhu”

“Integrating single-cell and spatial transcriptomics to understand rice root development”

New York, USA, August 2019
Mechanisms of Plant Development, FASEB
“By Mingyuan Zhu”

“Timing of organ initiation by hormone signaling is critical for robust organ size”

Quebec, Canada, August 2018
9th International Plant Biomechanics Conference
“By Mingyuan Zhu”

“A MYB domain protein controls organ size uniformity through affecting cell wall stiffness in Arabidopsis”

Services

November 2023 – Present
Elected North American Early Career Scholar
“Mingyuan Zhu”

North American Arabidopsis Steering Committee (NAASC) Serve as a member of the Diversity, Equity, Inclusion, and Belonging Award committee.
Organize the “Exploring Career Opportunities in Academia & Industry Panel” workshop at ICAR 2024.
Co-chair the “Sustainable Crops/Food/Bioproducts, Improving Photosynthesis” plenary session at ICAR 2024.

August 2023 - Present
Committee Member
“Mingyuan Zhu”

Plant Cell Rubrics Committee - Plant Cell Atlas (PCA)Organize and nominate speakers for an online webinar series “What are plant cell
states?”.

July 2024 at ICAR 2024
Founding Leader
“Mingyuan Zhu”

Founding Leader - Plant Method Exchange Platform (PMEX)
Officially launched: July 2024 at ICAR 2024
Official website: https://plant-methods.owlstown.net/

August 2023 - June 2024
Committee Member
“Mingyuan Zhu”

Local Organizing Committee - New Phytologist, Next Generation Scientists Conference
Organize two breakout sessions: “Career transitions for PhD/Postdoc: Environment, PhysDev, and Biotech”.
Co-chair the plenary session: “Session 6”.

June 2023 - Present
Member, Editorial Board
“Mingyuan Zhu”

Plant Morphogenesis and Evolution Section, Frontiers in Plant Physiology

June 2018 – December 2020
Associate faculty member
“Mingyuan Zhu”

F1000Prime (now H1Connect Faculty Opinions)
Write more than 15 recommendations for published manuscripts.
Recommendation example: https://doi.org/10.3410/f.737763007.793577589

April 2024
Outreach activity leader
“Mingyuan Zhu”

FEMMES+ Capstone program.
Designed and organized a one-day outreach program introducing students from Durham (4th through 6th grade) to plant biology concepts and techniques
Engaged 19 local elementary school students (18 Females) in hands-on experience with dissecting microscopes and confocal microscopes.

Contact

300 Olsen Blvd
Texas A&M University
College Station, TX 77843
Duke University
124 Science Drive
Durham, NC 27708

We don’t see things as they are; we see them as we are.

Publications

 Zhu, M.*, Hsu, C-W.*, Lucas, O. P., Taylor, I. W., La Cavera, S., Oliveira, D.M., Verma, L., Mehra, P., Mijar, M., Sadanandom, A., Perez-Cota, F., Boerjan. W., Nolan, T. M., Bennett, M. J., Benfey, P. N., Pandey, B. K. (2025) Single-cell transcriptomics reveal how root tissues adapt to soil stress. Nature, 642, 721–729.

https://doi.org/10.1038/s41586-025-08941-z

Kong, S., Rusnak, B., Zhu, M., Roeder, A. H. (2025) Stochastic gene expression in auxin signaling in the floral meristem of Arabidopsis thaliana. Nature Communications 16 (1), 4682.

https://doi.org/10.1101/2025.03.02.640043 (bioRxiv)

 Kong, S., Rusnak, B., Zhu, M., Roeder, A. H. (2025) Stochastic gene expression in auxin signaling in the floral meristem of Arabidopsis thaliana. Nature Communications 16 (1), 4682.

https://doi.org/10.1016/j.devcel.2024.08.010

Kong, S. *, Zhu, M.*, Scarpin, M.R., Pan, D., Jia, L., Martinez, R.E., Alamos, S., Vadde, B.V., Garcia, H.G., Qian, SB., Brunkard, J.O. Roeder, A. H. (2024). DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins. Developmental Cell, 59(23), pp.3141-3160.

https://doi.org/10.1016/j.devcel.2024.08.010

Kong, S., Zhu, M., Pan, D., Lane, B., Smith, R. S., & Roeder, A. H. (2024). Tradeoff Between Speed and Robustness in Primordium Initiation Mediated by Auxin-CUC1 Interaction. Nature Communications, 15(1), 5911.

https://doi.org/10.1038/s41467-024-50172-9

Kong, S., Zhu, M., and Roeder, A. H. (2024). Self-organization underlies developmental robustness in plants. Cells & Development 203936. Invited review

https://doi.org/10.1016/j.cdev.2024.203936

 Zhu, M., & Benfey, P. N. (2023). Plant physiology: The to-and-fro of hormone signals to respond to drought. Current Biology, 33(3), R114-R117.

https://doi.org/10.1016/j.cub.2022.12.007

Zhu, M.*, Taylor, I. W.*, & Benfey, P. N (2022). Single-cell genomics revolutionizes plant development studies across scales. Development, 149(6), dev200179. Invited review

https://doi.org/10.1242/dev.200179

 Rajanala, A., Zhu, M., Taylor, I.W., Pierce, C. J., Hales, M., Benfey, P.N., & Goldman, D.I. (2022). Modeling plant root circumnutation using cellular simulation. Bulletin of the American Physical Society. (2024), Y03. 013

Shao, Y., Lehner, K. R., Zhou, H., Taylor, I., Zhu, M., Mao, C. ^, & Benfey, P. N. (2021). VAP-RELATED SUPPRESSORS OF TOO MANY MOUTHS (VST) family proteins are regulators of root system architecture. Plant Physiology, 185(2), 457-468.

https://doi.org/10.1093/plphys/kiaa036

Zhu, M., Chen, W., Mirabet, V., Hong, L., Bovio, S., Strauss, S., Schwarz, E., Tsugawa, S., Wang, Z., Smith, R.S., Li, C.-L., Hamant, O., Boudaoud, A.^, and Roeder, A.H.K. (2020) Robust organ size requires robust timing of initiation orchestrated by focused auxin and cytokinin signaling. Nature Plants, 6(6), 686-698.

https://doi.org/10.1038/s41477-020-0666-7

Ripoll, J. J*., Zhu, M*., Brocke, S., Hon, C. T., Yanofsky, M. F., Boudaoud, A., & Roeder, A. H. (2019). Growth dynamics of the Arabidopsis fruit is mediated by cell expansion. Proceedings of the National Academy of Sciences, 116(50), 25333-25342.

https://doi.org/10.1073/pnas.1914096116

Zhu, M., & Roeder, A. H. (2020). Plants are better engineers: the complexity of plant organ morphogenesis. Current Opinion in Genetics & Development, 63, 16-23. Invited review

https://doi.org/10.1016/j.devcel.2024.08.010

 Hong, L., Dumond, M., Zhu, M., Tsugawa, S., Li, C.B., Boudaoud, A., Hamant, O. and Roeder, A.H., (2018). Heterogeneity and robustness in plant morphogenesis: from cells to organs. Annual Review of Plant Biology, 69, pp.469-495. Invited review

https://doi.org/10.1146/annurev-arplant-042817-040517

Hong, L.*, Dumond, M.*, Tsugawa, S.*, Sapala, A, Routier-Kierzkowska, A.-L., Zhou, Y., Chen C., Kiss, A., Zhu, M., Hamant, O., Smith, R.S., Komatsuzaki, T., Li, C.-L., Boudaoud, A, and Roeder, A.H.K. (2016) Variable cell growth yields reproducible organ development through spatiotemporal averaging. Developmental Cell, 38(1), 15-32.

https://doi.org/10.1016/j.devcel.2016.06.016